Can Ketamine and MDMA treat trauma?

Hi all! This weeks video looks at the effects of MDMA/ecstasy and ketamine as a treatment option for ptsd. The biological mechanisms involved in these drugs for ptsd as well as depression/anxiety are mentioned, as well as the therapeutic benefits and research in the area.

If you have any questions about the video or any ideas for future videos, please comment below! 🙂

0:00 Intro
00:31 Glutamate and PTSD
01:30 PTSD general symptoms
02:13 Current PTSD medications
02:31 Ketamine: biology
03:21 Ketamine research
03:55 Ketamine: biology & psychology
05:30 Ketamine treatment review
06:44 Ketamine: summary
07:20 MDMA intro
07:35 MDMA psychology/biology
08:29 Fear extinction learning
09:09 MDMA & therapy
11:34 MDMA general research comment
12:17 MDMA review
13:03 Video summary


Averill et al. (2016). Glutamate Dysregulation and Glutamatergic Therapeutics for PTSD: Evidence from Human Studies. Neurosci Lett, 649, 147–155.

Chambers et al. (1999). Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Semin Clin Neuropsychiatry, 4(4):274-81. doi: 10.153/SCNP00400274.

Liriano et al. (2019). Ketamine as treatment for post-traumatic stress disorder: a review. Drugs Context, 8. doi: 10.7573/dic.212305

Sessa. (2017). MDMA and PTSD treatment: “PTSD: From novel pathophysiology to innovative therapeutics”. Neuroscience Letters, 649, 176-180.

Feduccia and Mithoefer. (2018). MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms? Progress in Neuro-Psychopharmacology and Biological Psychiatry, 84(A), 221-228.

Illingworth et al. (2020). A comparison of MDMA-assisted psychotherapy to non-assisted psychotherapy in treatment-resistant PTSD: A systematic review and meta-analysis. J Psychopharmacoly, 20. doi: 10.1177/0269881120965915.

Young et al. (2017). Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA). Psychopharmacology (Berl). 2017 Oct; 234(19): 2883–2895.

Source: Youtube