GC#11 Matthew Hill: Stress, PTSD & Endocannabinoid Biology



Nick talks to Dr. Matthew Hill about the role of the endocannabinoid system in regulating stress and emotional behavior.

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About Nick Jikomes:

Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, the world’s largest cannabis information resource. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

0:00 Intro
0:55 The Woman Who Can’t Feel Pain or Anxiety
8:17 Anandamide, “the bliss molecule”
10:00 Evolutionary Basis For Anxiety
13:16 Endocannabinoid System (ECS)
20:05 Precise Regulation of ECS
21:37 Why Cannabis Can Have Different Effects
25:37 Dose-Dependent Effects of Cannabinoids
29:00 ECS as a “Stress Buffer”
33:54 PTSD
38:31 Cannabis, Sleep, Dreams & PTSD
44:04 MDMA & FAAH-inhibitors for PTSD
46:57 Fear Extinction & Learning
52:08 FAAH-inhibitor Side-Effects
54:08 Clinical Work on FAAH-inhibitors
1:01:14 Brain-Body Interactions
1:04:44 Pain vs. Stress vs. Anxiety
1:09:25 CBD
1:15:54 Bioavailability & Routes of Administration
1:17:30 Entourage Effects
1:28:06 Medical Research on THC & CBD
1:33:25 New Animal Research on Inhaled Cannabis
1:42:10 Final Thoughts

Source: Youtube