MDMA-Assisted Psychotherapy Improves PTSD Symptoms For Up To 3 Years: MAPS Phase 2 Follow Up Results



#neuroscience #psilocybin #MDMA #depression #psychedelicmedicine
From NeuroBeer #4 – streamed live June 15, 2020.
Full conversation: https://youtu.be/yhxyuBLiLs8

How long does it take for psychedelic drugs like MDMA or magic mushrooms (psilocybin) to have therapeutic effects for depression or ptsd treatment? How long do these antidepressant actions of MDMA & psilocybin last? And How do these psychedelic drugs produce their beneficial effects in the brain to begin with? Serotonin receptors vs metabotropic glutamate receptors involved?

These highly anticipated results follow-up with patients treated with MDMA-assisted psychotherapy 1+ years after treatment to evaluate how long the benefits last for. These freshly published results are derived from six separate phase 2 clinical trials that were published June 3rd in the journal Psychopharmacology.

We’re a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis.

In this clip we comment on the recent phase-2 follow up studies from the Multidisciplinary Association For Psychedelic Studies (MAPS). In September 2019 the first results from pooled analyses of 6 double blinded and randomized studies assessing MDMA for PTSD management entitled, “Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline”.
More than 1 year has passed since the initial trials were completed, and in June 2020 the results from the 1+ year follow up study of these same individuals were reported. We explore these results and possible mechanisms underlying MDMA and psilocybin assisted psychotherapy for depression and ptsd.

open access article phase-2 follow up study: https://link.springer.com/article/10.1007/s00213-020-05548-2

Original Phase 2 pooled analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751381/

Additional resources from MAPS: https://maps.org/research/mdma/ptsd/phase3
&
https://maps.org/research/mdma/mdma-research-timeline

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